Pengaruh Jumlah Tranfusi Trombosit Concentrate Terhadap Kenaikan Kadar Trombosit pada Pasien Trombositopenia
Keywords:
Thrombocyte Concentrate, Thrombocytopenia, Blood TransfusionAbstract
Thrombocytopenia is a condition characterized by a decrease in platelet count below normal levels, which increases the risk of bleeding and therefore requires management through Thrombocyte Concentrate (TC) transfusion. This study aims to analyze the effect of the number of TC transfusion units on the increase in platelet levels in patients with thrombocytopenia. A quantitative descriptive approach was employed, involving a total of 34 patients selected using a total sampling technique. The data used were secondary data obtained from the recapitulation of platelet count reports before and after TC transfusion, as well as patient medical records at RSUD Pringsewu in 2024. Data analysis was conducted using simple linear regression analysis. The results showed a significance value of 0.004 (Sig. < 0.05), indicating a statistically significant effect of the number of TC transfusion units on the increase in platelet levels in patients with thrombocytopenia. It can be concluded that a higher number of Thrombocyte Concentrate transfusion units administered is associated with a greater increase in platelet levels in thrombocytopenic patients.
References
Adiputra, I.M.S., Trisnadewi, N.W., Oktaviani, N.P.W. & Munthe, S.A. (2021) Metodologi penelitian kesehatan.
Asmarani, E. (2021) Penatalaksanaan trombositopenia pada pasien dengue hemorrhagic fever. Skripsi. STIKes Insan Cendekia Medika Jombang.
Astuti, D. & Maharani, E.A. (2021) ‘Nilai indeks trombosit sebagai kontrol kualitas komponen konsentrat trombosit’, Meditory: The Journal of Medical Laboratory, 8(2), pp. 85–94.
Eriksson, L., Kristensen, J. & Olsson, K. (2008) ‘Evaluation of platelet function using the in vitro bleeding time and corrected count increment of transfused platelets: Comparison between platelet concentrates derived from pooled buffy coats and apheresis’, Vox Sanguinis.
Hoffbrand, A.V. & Moss, P.A.H. (2014) Kapita selekta hematologi. Edisi ke-6. Alih bahasa oleh Pendit, B.U., Setiawan, L. & Iriani, A. Editor edisi Bahasa Indonesia: Sandra, F. Jakarta: EGC.
Jinna, S. & Khandhar, P.B. (2023) ‘Thrombocytopenia’, National Library of Medicine, 24.
Kementerian Kesehatan Republik Indonesia (2017) Pedoman dan standar etik penelitian dan pengembangan kesehatan nasional. Jakarta: Kementerian Kesehatan RI.
Kementerian Kesehatan Republik Indonesia (2022) Idiopatik trombositopenik purpura. Jakarta: Kementerian Kesehatan RI.
Kessler, C. (2023) Immune thrombocytopenia (ITP) workup.
Khan, A.I. & Anwer, F. (2023) ‘Platelet transfusion’, dalam Current & Emerging Treatments for Immune Thrombocytopenia, pp. 103–110. https://doi.org/10.2217/EBO.12.321
Kiswari, R. (2014) Hematologi dan transfusi. Jakarta: Erlangga.
Mahira, D.E., Roosarjani, C. & Laili, N.H. (2023) ‘Gambaran permintaan thrombocyte concentrate untuk pasien trombositopenia di UDD PMI Kota Surakarta Triwulan III Tahun 2021’, IJM: Indonesian Journal of Multidisciplinary, 1(3), pp. 1122–1130.
Moulis, G., Christiansen, C.F., Darvalics, B. & Nørgaard, M. (2018) ‘Prevalence of thrombocytopenia and thrombocytosis upon acute hospital admission to internal medicine units: A cross-sectional study in Denmark’, European Journal of Internal Medicine, 57, pp. 34–37.
Peraturan Menteri Kesehatan Republik Indonesia Nomor 91 Tahun 2015 tentang Standar Pelayanan Transfusi Darah (2015).
Purwanto, N. (2019) ‘Variabel dalam penelitian pendidikan’, Jurnal Teknodik, 6(1), pp. 196–215. https://doi.org/10.32550/teknodik.v0i0.554
Rafika, R., Amelia, D., Naim, N. & Hasen, Z.A. (2021) ‘Perbandingan kualitas thrombocyte concentrate dari platelet rich plasma dan platelet apheresis pada jumlah trombosit dan residu leukosit’, Jurnal Analis Kesehatan, 10(1), pp. 22–28.
Republik Indonesia, Menteri Kesehatan (2015) Peraturan Menteri Kesehatan Republik Indonesia Nomor 91 Tahun 2015 tentang Standar Pelayanan Transfusi Darah.
Rosyidah, R.A., Anjani, N., Hartini, W.M. & Mardianingsih, A. (2023) ‘Perbedaan jumlah trombosit pasca transfusi thrombocyte concentrate dan thrombocyte apheresis pada pasien trombositopenia’, Jurnal Kesehatan, 11(2), pp. 169–182.
Safitri, Z. & Maulana, M.R. (2023) ‘Jumlah trombosit pada produk darah thrombocyte concentrate masa simpan I, III dan V hari di Unit Transfusi Darah (UTD) Palang Merah Indonesia (PMI) Kota Pekalongan’, Jurnal Dunia Ilmu Kesehatan (JURDIKES), 1, pp. 12–15.
Situmorang, P.R., Debataraja, M.M.H.R., Tarigan, R.V.B. & Manik, C. (2023) ‘Perbedaan jumlah konsentrat trombosit pada penyimpanan hari 1, 3, dan 5 di Unit Donor Darah PMI Kota Medan’, Jurnal Kesehatan Tambusai, 4(3), pp. 4380–4385.
Sugiyono (2012) Metode penelitian kuantitatif, kualitatif dan R&D. Bandung: Alfabeta.
Supadmi, F.R.S. (2021) ‘Gambaran pengguna komponen thrombocyte concentrate (TC) di UTD PMI Kabupaten Sleman Tahun 2019’, Jurnal Ilmiah Cerebral Medika, 3(1), pp. 2–2.
Syafitri, R. & Shoumi, D. (2021) ‘Perbedaan kadar trombosit pada pasien trombositopenia sebelum dan sesudah transfusi trombosit konsentrat di RSUD Karawang Tahun 2019–2020’, Jurnal Kesehatan, 3(5), pp. 107–111.
Waruwu, M. (2023) ‘Pendekatan penelitian pendidikan: Metode penelitian kualitatif, metode penelitian kuantitatif dan metode penelitian kombinasi (mixed method)’, Jurnal Pendidikan Tambusai, 7(1), pp. 2896–2910.
Wundiawan, K.F., Aryasa, T.E.M. & Wiryana, M. (2023) ‘Manajemen anestesi perioperatif pada kehamilan dengan trombositopenia’, Jurnal Anestesi Obstetri Indonesia, 6(1), pp. 54–59.
Yuni, N.E. (2015) Kelainan darah. Yogyakarta: Nuha Medika.
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